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. Author manuscript; available in PMC: 2019 Apr 16.
Published in final edited form as: J Phys Chem B. 2019 Mar 4;123(13):2792–2800. doi: 10.1021/acs.jpcb.8b12517

Figure 7. Example logic switches induced by the third ligand.

Figure 7.

Parameter conditions and representative activity plots of an allosteric molecule exhibiting AND logic in the absence of the third ligand, while exhibiting OR logic (A,B) or YES1 logic (C,D) when L3 is present at a saturating concentration. Parameters used were KA,i = 2.5 × 10−8 M and KI,i = 2.5 × 10−4 M in Panel B, KA,i = 2.5 × 10−8 M, KI,1 = 2.5 × 10−4 M and KI,2/3 = 2.5 × 10−6 M in panel D, along with ∆εAI = −12 kBT in both panels.