Figure 1.

Enthesis structure. The healthy tendon–bone interface consists of a functionally graded transition from tendon to the interface which progresses from non-mineralized fibrocartilage to mineralized fibrocartilage to bone (top left). The ligament-bone and tendon-bone are histologically similar but current treatments for tissue injury differ clinically.⁶⁷ In contrast, a healing interface consists of scar tissue (bottom left).The ligament-bone interface shows a similar transition from ligament to bone (top right), with a spectroscopic map showing a gradient from high collagen (red) to low collagen (blue) (bottom right).^18,22