Table 2.
Comparison of Outcomes of Patients with Sepsis Response Signature 1 and 2 Phenotypes Given Either Hydrocortisone or Placebo as Study Drug 2
| SRS1 |
SRS2 |
P Value for Interaction | |||
|---|---|---|---|---|---|
| Hydrocortisone | Placebo | Hydrocortisone | Placebo | ||
| n | 27 | 35 | 31 | 24 | |
| Kidney failure–free days, median (IQR), d | 25 (1–28) | 25 (9–28) | 25 (4–28) | 28 (25–28) | 0.43* |
| 28-d mortality, n/total (%) | 9/27 (33) | 13/35 (37) | 13/31 (42) | 2/24 (8) | 0.02† |
| ICU mortality, n/total (%) | 7/27 (26) | 9/35 (26) | 11/31 (35) | 2/24 (8) | 0.08† |
| Hospital mortality, n/total (%) | 8/27 (30) | 12/35 (34) | 13/31 (42) | 2/24 (8) | 0.02† |
| Kidney failure, n/total (%) | 13/27 (48) | 19/35 (54) | 17/31 (55) | 10/24 (42) | 0.30† |
| No. weaned from vasopressors for >24 h, n/total (%) | 25/27 (93) | 31/35 (89) | 28/31 (90) | 23/24 (96) | 0.36† |
| Time to shock reversal, median (IQR), h | 30.6 (18.1–77.7) | 43.8 (21.5–91.5) | 58.9 (36.1–82.3) | 89.5 (31.5–122.0) | 0.60‡ |
| Duration of mechanical ventilation, median (IQR), d | 3.0 (2.0–12.0) | 6.0 (2.0–11.5) | 6.0 (2.0–14.5) | 9.0 (6.0–20.0) | 0.67* |
| Mean total SOFA score, median (IQR) | 5.7 (3.6–9.0) | 4.9 (3.6–7.2) | 5.6 (3.7–8.3) | 4.7 (3.5–6.3) | 0.72§ |
Definition of abbreviations: IQR = interquartile range; SOFA = Sequential Organ Failure Assessment score; SRS = sepsis response signature.
Bold type indicates P < 0.05.
*
From the aligned rank transform test.
†
From logistic regression.
‡
From Cox regression, treating deaths as never having the event of interest. Results were similar treating death as a competing risk.
§
From linear regression, applying a square root transform to the outcome.