Table 1.

Peripheral neuropathy according to NCI-CTC Version 4.0

Adverse event	Grade
	1	2	3	4	5
Peripheral motor neuropathy	Asymptomatic, clinical or diagnostic observations only, intervention not indicated	Moderate symptoms, limiting instrumental ADL	Severe symptoms, limiting self-care ADL, assistive device indicated	Life-threatening consequences, urgent intervention indicated	Death
Peripheral sensory neuropathy	Asymptomatic, loss of deep tendon reflexes or paresthesia	Moderate symptoms, limiting instrumental ADL	Severe symptoms, limiting self-care ADL	Life-threatening consequences, urgent intervention indicated	Death
Neuralgia	Mild pain	Moderate pain, limiting instrumental ADL	Severe pain, limiting self-care ADL	–	–

Note: Data from National Cancer Institute.⁷

Abbreviations: NCI-CTC, National Cancer Institute – Common Toxicity Criteria; ADL, activities of daily living.