Table 3.
Reference | N | Chemo regimen | CR (%) | Relapsea (%) | Median overall survival (months) |
---|---|---|---|---|---|
Feuillard et al9 | 5 | ALL | 80 | 50 | 12 |
6 | AML | 100 | 100 | 14.5 | |
10 | Lymphoma | 80 | 75 | 11 | |
Dalle et al39 | 5 | ALL | 80 | nr | 16 |
10 | AML | 40 | nr | 19 | |
20 | Lymphoma | 50 | nr | 11.5 | |
Tsagarakis et al40 | 9 | ALL | 100 | 33.3 | nr |
6 | AML | 50 | 33.3 | nr | |
4 | Lymphoma | 75 | 66.7 | nr | |
Dietrich et al41 | 3 | ALL | 100 | 66.7 | 23 |
2 | AML | 50 | 100 | 19 | |
1 | Lymphoma | 100 | 100 | 6 | |
Lucioni et al29 | 9 | ALL | 78 | 29 | 12 |
4 | Lymphoma | 50 | 100 | 27.5 | |
Hashikawa et al42 | 2 | ALL | 100 | nr | NR |
4 | AML | 25 | nr | 5.5 | |
11 | Lymphoma | 73 | nr | 11 | |
Pagano et al14 | 15 | ALL/lymphoma | 67 | 60 | 12.3 |
26 | AML | 27 | 0 | 7.1 | |
An et al43 | 3 | ALL | 67 | 0 | 15.1 |
1 | AML | 0 | NA | ||
2 | Lymphoma | 50 | 0 | ||
Kim et al44 | 4 | Hyper-CVAD | 50 | 100 | 17 |
2 | ALL-like | 100 | 100 | ||
Martín- Martín et al38 | 7 | ALL | 100 | 43 | NR |
9 | AML | 100 | 78 | 11 | |
9 | Lymphoma | 78 | 100 | 10 |
Notes: Lymphoma (CHOP/CHOP-like).
% relapse out of those achieving a CR with induction. Some studies include patients who received HSCT in consolidation or in first relapse.
Abbreviations: nr, not reported; NR, not reached; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CVAD, cyclophosphamide, vincristine, doxorubicin, and dexamethasone; CR, complete remission; NA, not applicable; HSCT, hematopoietic stem cell transplantation.