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Acute thrombosis (0–30 days after diagnosis of VTE)
| Platelet count (109/L) (posttransfusion) | Platelet transfusiona | Anticoagulant dosage |
|---|---|---|
| Platelets ≥50 | No | Dalteparin 200 U/kg SC once daily/full-dose LMWH |
| Platelets 20–50 | Yes | Dalteparin 100 U/kg SC once daily/half-dose LMWH |
| Platelets <20 | Yes | Hold anticoagulation |
Note:
Transfusion to platelet count ≥20×109/L to allow at least 50% anticoagulant dose.
Abbreviations: VTE, venous thromboembolism; LMWH, low-molecular-weight heparin.
