Table 2.

Clinical evaluation of newly diagnosed SMM

Initial evaluation	History of present illness and past medical history
	Physical examination
FBC, bone marrow aspirate and biopsy	Percentage of bone marrow infiltration by clonal plasma cells, flow cytometry, conventional cytogenetics, and fluorescence in situ hybridization analysis
Biochemical studies	Creatinine, calcium; ß2-microglobulin, LDH, albumin
Protein studies	Total serum protein, serum protein electrophoresis, 24-h urine sample protein electrophoresis, serum and urine immunofixation, SFLCs, SFLCR
Radiological studies	Skeletal survey (CT) or PET-CT; MRI of thoracic and lumbar spine and pelvis or WB-MRI

Note: Data from Rajkumar et al.²,⁵

Abbreviations: FBC, full blood count; LDH, lactate dehydrogenase; MRI, magnetic resonance imaging; PET-CT, positron emission tomography-computed tomography; SFLC, serum free light chain; SFLCR, serum free light chain ratio; SMM, smoldering multiple myeloma; WB-MRI, whole-body magnetic resonance imaging.