Table 10.

Phototoxicity studies of drometrizole

Subject/Number	Compound	Method	Results	Reference
Human patients suffering from light dermatoses and sensitivity, 145	Drometrizole 5% or 1.5 parts by weight	445 topical applications with radiation for 3 years	Hypersensitivity reactions in 2 cases	35
Human, 2 males and 8 females	Drometrizole 0.1% in suntan oil	Phototoxicity with UVA and UVB exposure	Nonphototoxic	49
Human, 2 males and 8 females	Drometrizole 0.1% in suntan oil	Phototoxicity with UVA and UVB exposure	Nonphototoxic	50
Human, 99	Drometrizole 0.03% in a nail product	Prophetic patch test with UV exposure	Nonirritating, nonsensitizing, and nonphotosensitizing	51
Human, 48	Drometrizole 0.03% in a nail product	RIPT with UV exposure	Nonirritating, nonsensitizing, and nonphotosensitizing	51