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Repeated toxicity studies of drometrizole
| Period | Animal, number | Compound | Dosage (mg/kg bw/day) | Results | Reference |
|---|---|---|---|---|---|
| 14 days to 28 days | Rats, 30 | Drometrizole | 300 | Increase in liver weight, change of several enzyme activity | 28 |
| 13 weeks | Dogs | Drometrizole | Male: 31.75, 95.25, 317.5 Female: 34.6, 103.8, 346 | Decrease in food intake and body weight gain, increase of serum enzyme activity | 26 |
| 2 years | Rats | Drometrizole | 4, 14, 47, 142 | Decrease in body weight in male and food intake in female | 26 |
