Table 7.

Summary of carcinogenicity studies of triclosan

Route	Species	Exposure period	Dose	Results	Ref.
Oral	Mouse	18 months	10, 30, 100, 200 mg/kg bw/day	Adenomas or carcinomas were observed in the liver in 6, 10, 17, 32, and 42 males, respectively and 0, 1, 3, 6, and 20 females, respectively. Triclosan in mice should be classified as a peroxisome proliferator with the possibility to cause liver cancer at a 30 mg/kg bw/day dose, but it is estimated that the possibility of liver cancer is not high in humans.	3
Oral	Hamster	90–95 weeks	12.5, 75, 250 mg/kg bw/day	Increased mortality and nephropathy at doses of 250 mg/kg bw/day	43
Dermal	Mouse	18 months	0.5, 1%	No carcinogenicity	41