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. 2019 Apr 16;17(4):e2006421. doi: 10.1371/journal.pbio.2006421

Fig 4. Oxytocin decreases locally evoked CeA GABAergic signaling and blunts alcohol effects.

Fig 4

(A) Representative eIPSPs recorded from CeA neurons of nondependent (upper) and dependent (lower) rats before (baseline) and during acute application of oxytocin (500 nM), oxytocin with alcohol (44 mM), and alcohol alone. (B) Effect of 3 concentrations of oxytocin (100, 500, and 1,000 nM) on eIPSP amplitudes in CeA neurons from alcohol-nondependent and -dependent rats. Higher concentrations of oxytocin (500 and 1,000 nM) decreased eIPSP amplitudes in nondependent but not in dependent rats. (C) Oxytocin blunted the alcohol-induced enhancement of eIPSP in neurons from both alcohol-nondependent and alcohol-dependent rats. *Significant effect of drug compared to baseline (p < 0.05). #Significant difference between groups (p < 0.05). CeA, central nucleus of the amygdala; eIPSP, evoked inhibitory postsynaptic potential; EtOH, ethanol; OT, oxytocin.