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. 2019 Apr 16;14(4):e0214924. doi: 10.1371/journal.pone.0214924

Table 4. Predictors of aggressive and violent behavior: generalized linear models (GLMs) with interaction effect between variables and groups (all sample), and corresponding GLMs for the two groups.

All sample Case patients group Control group
p-value AIC βcases βcontrols
Total MOAS
BDHI Negativism 0.039 1195.3 0.81** 1.08
SLOF Social acceptability/adjustment <0.001 1521.0 0.92** 0.75**
BPRS-E Total Score 0.019 1547.3 1.01 1.06**
Lifetime misuse of substances (No vs Yes) <0.001 1554.5 0.91 0.18**
Time spent doing nothing 0.008 1570.1 0.51** 1.43
BPRS-E Activation 0.001 1575.5 1.05** 1.23**
Age 0.014 1576.7 0.98** 0.94**
Primary diagnosis 0.023 1578.4 # #
Familiarity with psychiatric illness (Yes vs No) 0.063 1583.8 1.60** 0.81
Comorbidity with alcohol/substances misuse 0.028 1588.9 # #
Illness duration 0.005 1592.3 1.00 0.95**
Misuse of alcohol in the last 12 months (No vs Yes) 0.003 1593.3 1.04 0.33**
MOAS verbal aggression
SLOF Social acceptability/adjustment 0.002 1272.0 0.91** 0.77**
BPRS-E Total Score 0.018 1295.6 1.01 1.06**
Lifetime misuse of substances (No vs Yes) <0.001 1307.1 0.89 0.25**
BPRS-E Activation 0.008 1321.5 1.06** 1.19**
Age 0.011 1329.5 0.99 0.95**
Misuse of alcohol in the last 12 months (No vs Yes) 0.003 1332.9 0.95 0.31**
Comorbidity with alcohol/substances misuse 0.038 1334.3 $ $
BPRS-E Psychotic Symptoms 0.046 1334.8 1.00 1.09**
Illness duration 0.023 1339.1 1.00 0.96**
MOAS aggression against objects
SLOF Social acceptability/adjustment 0.012 700.5 0.89** 0.71**
Lifetime misuse of substances (No vs Yes) 0.001 707.4 1.40 0.16**
Illness duration 0.047 720.3 0.99 0.92**
Time spent doing nothing 0.023 721.1 0.59 3.00*
Misuse of alcohol in the last 12 months (No vs Yes) 0.056 722.8 0.90 0.24**
MOAS self-aggression
BDHI Indirect Aggression 0.025 246,5 0.98 1.99**
STAXI Feel like expressing anger physically 0.036 339,7 1.03** 0.97
STAXI Feeling angry 0.035 340,3 1.03** 0.97
STAXI Feel like expressing anger verbally 0.048 340,6 1.03** 0.97
STAXI Anger control-in 0.045 340,9 1.04** 0.97
Familiarity with psychiatric illness (Yes vs No) 0.005 360,3 4.67** 0.12**
Occupation (Yes vs No) 0.014 361,3 5.96** 0.34
MOAS physical aggression
BDHI Total Score 0.036 325.7 0.98 1.11*
STAXI Anger Expression Index 0.046 510.0 1.00 1.06**
Lifetime misuse of substances (No vs Yes) 0.001 549.1 0.91 0.03**
Age of first contact with DMHs 0.001 553.3 0.97 0.71**
SLOF Social acceptability/adjustment 0.012 556.5 0.99 0.69**
Misuse of alcohol in the last 12 months (No vs Yes) 0.039 563.8 0.53 0.06**
BPRS-E Activation 0.017 566.2 1.05 1.40**
Primary diagnosis 0.024 568.0 £ £
Time spent doing nothing 0.051 568.2 0.31** 2.02
Illness duration 0.029 570.3 1.03 0.92*

BDHI = Buss-Durkee Hostility Inventory; BPRS-E = Brief Psychiatric Rating Scale; MOAS = Modified Overt Aggression Scale; SLOF = Specific Levels of Functioning; STAXI-2 = Scale State-Trait Anger Expression Inventory 2.

p value: significance of the interaction term; AIC: Akaike Information Criterion of the GLM; βcases βcontrols: estimates of the variable effect in the two groups separately.

* Tendency towards significance (p≤0.1) of the beta coefficient

** Significance (p<0.05) of the β coefficient.

# Among cases, patients with a personality disorder are more violent than other diagnostic groups (p<0.048); among controls, patients with personality disorders are more violent than patients with schizophrenia (p<0.001). Among cases, there are no significant differences between patients with and without comorbidity of alcohol/substance abuse. Among controls, patients with a comorbidity of alcohol/substance abuse are more violent than patients who do not use alcohol and substances.

$ Among cases, there are no significant differences in verbal aggression between patients with and without comorbidity of alcohol/substance abuse. Among controls, patients with a comorbidity of alcohol/substance abuse are more verbally violent than patients who do not use alcohol and substances.

£ Among cases, there are no significant differences among different diagnostic groups; among controls, patients with personality disorders are more violent than patients with schizophrenia (p<0.047).