Table 3.

Summary of pairwise group differences in anterior insula to target network ROI functional connectivity.

				Bipolar vs HC			Unipolar vs HC			Bipolar vs Unipolar
Insula Seed Region	Fx Network	Target ROI	MNI Coordinates	Mean Δ (SE)a	pb	95% C.I. Lower, Upper	Mean Δ (SE)	pb	95% C.I. Lower, Upper	Mean Δ (SE)	pb	95% C.I. Lower, Upper
R. Dorsal Anterior
	ECN	L. IPL	−48 −48 48	−0.22 (.07)	<.001***	−0.35, −0.09	−0.08 (.05)	0.13	−0.19, 0.02	−0.14 (.05)	0.01*	−0.25, −0.03
		R. IPL	38 −56 44	−0.04 (.07)	0.56	−0.17, 0.09	0.04 (.05)	0.49	−0.07, 0.14	−0.08 (.05)	0.17	−0.18, 0.03
		L. DLPFC	−34 46 6	−0.09 (.08)	0.29	−0.25, 0.07	−0.05 (.06)	0.48	−0.17, 0.08	−0.04 (.07)	0.54	−0.17, 0.09
		R. DLPFC	46 46 14	−0.07 (.06)	0.28	−0.19, 0.06	0.02 (.05)	0.65	−0.08, 0.12	−0.09 (.05)	0.08	−0.19, 0.01
	SN	L. VLPFC	−38 52 10	−0.06 (0.07)	0.40	−0.20, 0.08	−0.06 (.06)	0.31	−0.17, 0.05	0.003 (.06)	0.96	−0.12, 0.11
		R. VLPFC	42 46 0	−0.17 (.08)	0.04	−0.32, −0.01	−0.11 (.06)	0.09	−0.23, 0.02	−0.06 (.06)	0.36	−0.19, 0.07
		L. dACC	−6 18 30	0.07 (.06)	0.27	−0.06, 0.19	0.01 (.05)	0.91	−0.09, 0.10	0.06 (.05)	0.23	−0.04, 0.17
		R. dACC	6 22 30	0.10 (.07)	0.19	−0.05, 0.24	0.05 (.06)	0.40	−0.07, 0.17	0.05 (.06)	0.45	−0.07, 0.17
	DMN	L. PCC	−7 −43 33	0.07 (.09)	0.45	−0.11, 0.25	−0.04 (.07)	0.59	−0.18, 0.10	0.11 (.07)	0.15	−0.04, 0.25
		R.PCC	7 −43 33	0.07 (.90)	0.44	−0.11, 0.26	0.03 (.07)	0.73	−0.12, 0.17	0.05 (.08)	0.55	−0.11, 0.20
		L. vmPFC	−2 36 10	0.10 (.08)	0.22	−0.06, 0.25	0.06 (.06)	0.31	−0.06, 0.19	0.03 (.06)	0.61	−0.10, 0.16
		R. vmPFC	2 36 10	0.06 (.08)	0.42	−0.09, 0.22	0.05 (.06)	0.40	−0.07, 0.17	0.01 (.06)	0.87	−0.12, 0.14
L. Dorsal Anterior
	ECN	L. IPL	−48 −48 48	−.17 (.06)	0.003**	−0.29, −0.06	−0.12 (.05)	0.01*	−0.21, −0.03	−0.05 (.05)	0.25	−0.15, 0.04
		R. IPL	38 −56 44	−0.01 (.06)	0.92	−0.13, 0.12	0.003 (.05)	0.95	−0.10, 0.10	−0.01 (.05)	0.85	−0.11, 0.09
		L. DLPFC	−34 46 6	−0.04 (0.8)	0.59	−0.19, 0.11	−0.04 (.06)	0.48	−0.16, 0.08	0.003 (.06)	0.97	−0.12, 0.13
		R. DLPFC	46 46 14	−0.06 (.06)	0.34	−0.18, 0.06	−0.01 (.05)	0.82	−0.11, 0.09	−0.05 (.05)	0.34	−0.15, 0.05
	SN	L. VLPFC	−38 52 10	−04 (.07)	0.56	−0.17, 0.09	−0.07 (0.06)	0.22	−0.17, 0.04	0.03 (.06)	0.63	−0.08, 0.14
		R. VLPFC	42 46 0	−0.11 (.07)	0.14	−0.24, 0.03	−0.08 (.06)	0.15	−0.19, 0.03	−0.02 (.06)	0.69	−0.14, 0.09
		L. dACC	−6 18 30	0.02 (.06)	0.75	−0.11, 0.14	−0.01 (.05)	0.77	−0.11, 0.08	0.03 (.05)	0.50	−0.07, 0.13
		R. dACC	6 22 30	−0.06 (.07)	0.40	−0.08, 0.20	0.01 (.06)	0.84	−0.10, 0.12	0.05 (.06)	0.41	−0.07, 0.16
	DMN	L. PCC	−7 −43 33	−0.002 (.09)	0.99	−0.18, 0.19	0.01 (.07)	0.86	−0.13, 0.16	−0.01 (.08)	0.89	−0.16, 0.14
		R.PCC	7 −43 33	0.03 (.09)	0.75	−0.15, 0.21	0.06 (.07)	0.43	−0.08, 0.20	−0.03 (.07)	0.71	−0.17, 0.12
		L. vmPFC	−2 36 10	0.06 (.07)	0.41	−0.09, 0.21	0.13 (.06)	0.03	0.02, 0.25	−0.07 (.06)	0.25	−0.19, 0.05
		R. vmPFC	2 36 10	0.04 (.07)	0.57	−0.10, 0.19	0.12 (.06)	0.05	0.00, 0.23	−0.07 (.06)	0.22	−0.19, 0.05

Note: Results of MANCOVA model-adjusted pairwise comparisons between groups.

^aDifference in estimated marginal means.

^bUncorrected significance probabilities. Uncorrected significant findings denoted in bold font. Bonferroni corrected p-values denoted at

^***p<.001,

^**p<.01,

^*p<.05. ECN = frontoparietal executive control network. SN = salience network. DMN = default mode network. dACC = dorsal anterior cingulate cortex. DLPFC = dorsolateral prefrontal cortex. IPL = inferior parietal lobule. PCC = posterior cingulate cortex. VLPFC = ventrolateral prefrontal cortex. vmPFC = ventromedial prefrontal cortex.