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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Feb 7;3(5):473–484. doi: 10.1016/j.bpsc.2018.01.013

Table 3.

Summary of pairwise group differences in anterior insula to target network ROI functional connectivity.

Bipolar vs HC
Unipolar vs HC
Bipolar vs Unipolar
Insula
Seed
Region
Fx
Network
Target
ROI
MNI
Coordinates
Mean Δ
(SE)a
pb 95% C.I.
Lower,
Upper
Mean Δ
(SE)
pb 95% C.I.
Lower,
Upper
Mean Δ
(SE)
pb 95% C.I.
Lower,
Upper
R. Dorsal Anterior
ECN L. IPL −48 −48 48 −0.22 (.07) <.001*** −0.35, −0.09 −0.08 (.05) 0.13 −0.19, 0.02 −0.14 (.05) 0.01* −0.25, −0.03
R. IPL 38 −56 44 −0.04 (.07) 0.56 −0.17, 0.09 0.04 (.05) 0.49 −0.07, 0.14 −0.08 (.05) 0.17 −0.18, 0.03
L. DLPFC −34 46 6 −0.09 (.08) 0.29 −0.25, 0.07 −0.05 (.06) 0.48 −0.17, 0.08 −0.04 (.07) 0.54 −0.17, 0.09
R. DLPFC 46 46 14 −0.07 (.06) 0.28 −0.19, 0.06 0.02 (.05) 0.65 −0.08, 0.12 −0.09 (.05) 0.08 −0.19, 0.01
SN L. VLPFC −38 52 10 −0.06 (0.07) 0.40 −0.20, 0.08 −0.06 (.06) 0.31 −0.17, 0.05 0.003 (.06) 0.96 −0.12, 0.11
R. VLPFC 42 46 0 −0.17 (.08) 0.04 −0.32, −0.01 −0.11 (.06) 0.09 −0.23, 0.02 −0.06 (.06) 0.36 −0.19, 0.07
L. dACC −6 18 30 0.07 (.06) 0.27 −0.06, 0.19 0.01 (.05) 0.91 −0.09, 0.10 0.06 (.05) 0.23 −0.04, 0.17
R. dACC 6 22 30 0.10 (.07) 0.19 −0.05, 0.24 0.05 (.06) 0.40 −0.07, 0.17 0.05 (.06) 0.45 −0.07, 0.17
DMN L. PCC −7 −43 33 0.07 (.09) 0.45 −0.11, 0.25 −0.04 (.07) 0.59 −0.18, 0.10 0.11 (.07) 0.15 −0.04, 0.25
R.PCC 7 −43 33 0.07 (.90) 0.44 −0.11, 0.26 0.03 (.07) 0.73 −0.12, 0.17 0.05 (.08) 0.55 −0.11, 0.20
L. vmPFC −2 36 10 0.10 (.08) 0.22 −0.06, 0.25 0.06 (.06) 0.31 −0.06, 0.19 0.03 (.06) 0.61 −0.10, 0.16
R. vmPFC 2 36 10 0.06 (.08) 0.42 −0.09, 0.22 0.05 (.06) 0.40 −0.07, 0.17 0.01 (.06) 0.87 −0.12, 0.14
L. Dorsal Anterior
ECN L. IPL −48 −48 48 −.17 (.06) 0.003** −0.29, −0.06 −0.12 (.05) 0.01* −0.21, −0.03 −0.05 (.05) 0.25 −0.15, 0.04
R. IPL 38 −56 44 −0.01 (.06) 0.92 −0.13, 0.12 0.003 (.05) 0.95 −0.10, 0.10 −0.01 (.05) 0.85 −0.11, 0.09
L. DLPFC −34 46 6 −0.04 (0.8) 0.59 −0.19, 0.11 −0.04 (.06) 0.48 −0.16, 0.08 0.003 (.06) 0.97 −0.12, 0.13
R. DLPFC 46 46 14 −0.06 (.06) 0.34 −0.18, 0.06 −0.01 (.05) 0.82 −0.11, 0.09 −0.05 (.05) 0.34 −0.15, 0.05
SN L. VLPFC −38 52 10 −04 (.07) 0.56 −0.17, 0.09 −0.07 (0.06) 0.22 −0.17, 0.04 0.03 (.06) 0.63 −0.08, 0.14
R. VLPFC 42 46 0 −0.11 (.07) 0.14 −0.24, 0.03 −0.08 (.06) 0.15 −0.19, 0.03 −0.02 (.06) 0.69 −0.14, 0.09
L. dACC −6 18 30 0.02 (.06) 0.75 −0.11, 0.14 −0.01 (.05) 0.77 −0.11, 0.08 0.03 (.05) 0.50 −0.07, 0.13
R. dACC 6 22 30 −0.06 (.07) 0.40 −0.08, 0.20 0.01 (.06) 0.84 −0.10, 0.12 0.05 (.06) 0.41 −0.07, 0.16
DMN L. PCC −7 −43 33 −0.002 (.09) 0.99 −0.18, 0.19 0.01 (.07) 0.86 −0.13, 0.16 −0.01 (.08) 0.89 −0.16, 0.14
R.PCC 7 −43 33 0.03 (.09) 0.75 −0.15, 0.21 0.06 (.07) 0.43 −0.08, 0.20 −0.03 (.07) 0.71 −0.17, 0.12
L. vmPFC −2 36 10 0.06 (.07) 0.41 −0.09, 0.21 0.13 (.06) 0.03 0.02, 0.25 −0.07 (.06) 0.25 −0.19, 0.05
R. vmPFC 2 36 10 0.04 (.07) 0.57 −0.10, 0.19 0.12 (.06) 0.05 0.00, 0.23 −0.07 (.06) 0.22 −0.19, 0.05

Note: Results of MANCOVA model-adjusted pairwise comparisons between groups.

a

Difference in estimated marginal means.

b

Uncorrected significance probabilities. Uncorrected significant findings denoted in bold font. Bonferroni corrected p-values denoted at

***

p<.001,

**

p<.01,

*

p<.05. ECN = frontoparietal executive control network. SN = salience network. DMN = default mode network. dACC = dorsal anterior cingulate cortex. DLPFC = dorsolateral prefrontal cortex. IPL = inferior parietal lobule. PCC = posterior cingulate cortex. VLPFC = ventrolateral prefrontal cortex. vmPFC = ventromedial prefrontal cortex.