Table 1.
Univariable and multivariable associations of Aβ40 with subclinical cardiovascular disease and cardiorespiratory fitness
| Dependent variable | Univariable analysis | Multivariable analysis (Model 1) | Multivariable analysis (Model 2) |
|---|---|---|---|
| LV mass index, g/m2 | −0.04 (0.09) | −0.003 (0.88) | −0.016 (0.48) |
| LV SVI, m1/m2 | −0.057 (0.02) | −0.014(0.59) | −0.028 (0.28) |
| LVEF, % | 0.008 (0.741) | −0.022 (0.40) | −0.017 (0.55) |
| LA emptying fraction, % | −0.049 (0.06) | −0.067 (0.03) | −0.065 (0.08) |
| *hs-cTnT, pg/ml | 0.067 (0.002) | 0.041 (0.04) | 0.026 (0.21) |
| NT-proBNP, pg/ml | 0.141 (<0.001) | 0.088 (<0.001) | 0.067 (0.001) |
| *CAC, Agatston units | 0.062 (0.001) | −0.001 (0.98) | 0.009 (0.65) |
| Treadmill VO2 max, ml/kgr per min | −0.058 (0.002) | −0.044 (0.02) | −0.045 (0.02) |
Numbers indicate standardized beta coefficient and numbers in parentheses indicate P value, by linear regression analysis. Standardized coefficient represents the number of standard deviations the dependent variable will change per one standard deviation increase in Aβ40.
*indicates log transformed dependent variables.
Multivariable Model 1 includes age, gender, black race, hypertension, diabetes mellitus, smoking, hyperlipidemia, body mass index, hsCRP and estimated glomerular filtration rate.
Multivariable Model 2 includes age, gender, black race, education status, income, LDL, SBP, DBP diabetes mellitus, triglycerides, smoking, body mass index, hsCRP, microalbuminuria and estimated glomerular filtration rate.
In 15 subjects (0.49% of the population) Aβ40 concentrations were lower than the detection limit (<6pg/ml) of the ELISA used.
Abbreviations: Aβ40, amyloid beta 1–40 peptide; GFR, estimated glomerular filtration rate by the MDRD formula; VO2max, maximum oxygen consumption; LV, left ventricular; SVI, stroke volume index; LVEF, left ventricle ejection fraction; LA, left atrium; CAC, coronary artery calcium score; hs-cTnT, high sensitivity troponin T; NT-proBNP, N-terminal pro-brain natriuretic peptide; SBP, systolic blood pressure; DBP, diastolic blood pressure; hsCRP, high sensitivity C-reactive protein;