FIGURE 1.

Serum bicarbonate (HCO₃) increase and eGFR decline in chronic kidney disease (CKD) patients with metabolic acidosis (serum HCO₃ <22 mEq/l) treated with NaHCO₃ or sodium citrate supplementation versus control. Summary of changes in serum HCO3 (panel a) and estimated glomerular filtration rate (eGFR) decline (panel b) in CKD patients with metabolic acidosis (serum HCO₃ <22 mEq/l) treated with NaHCO₃ or sodium citrate supplementation (active) versus control patients. Data were extracted from the respective studies listed on the x-axis and cited in the reference section [15,16^▪▪,17,18^▪▪]; all values are mean changes from beginning to the end of the treatment period. The mean serum HCO₃ values at the end of treatment for the de Brito-Ashurst et al. [15] study were estimated from graphed data. CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; HCO₃, bicarbonate.