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. 2019 Apr 4;6(3):e561. doi: 10.1212/NXI.0000000000000561

Figure 4. C5B3 decreased NMOSD mouse model lesions in vivo.

Figure 4

We injected the mouse brains with 6 μL of IgGNMOSD and 4 μL of hC with or without 5 μL of C5B3. (A) GFAP, AQP4, and MBP immunofluorescence at 7 days after injection. The white lines delimit the lesion with AQP4, GFAP, and MBP loss. The yellow lines represent the needle tract. Scale bar is 500 μm. (B) High magnification of AQP4, GFAP, and MBP in injected hemispheres and noninjected contralateral hemispheres. Scale bar is 100 μm. The white dashed lines delimit the lesion. (C) Lesion size quantification from experiments. We used 1-way analysis of variance (ANOVA) to compare between the 3 groups; n = 5/group; *p < 0.05, **p < 0.01. AQP4 = aquaporin-4; GFAP = glial fibrillary acidic protein; MBP = myelin basic protein; NMOSD = neuromyelitis optica spectrum disorder.