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MOR partial agonism and antagonism by NFP in mMORCHO cells. Ligand concentration–effect for stimulation of [35S]GTPγS binding in membranes from mMOR-CHO cells was determined alone (A) or in the presence of 0.3 μM DAMGO (B). Data are the mean ± SEM (n = 4–5) of the percentage of maximal stimulation (produced by a maximally effective DAMGO concentration of 0.3 μM).
