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. Author manuscript; available in PMC: 2020 May 14.
Published in final edited form as: Biochem Biophys Res Commun. 2019 Mar 27;512(4):723–728. doi: 10.1016/j.bbrc.2019.03.120

Figure 1: Loss of ILC2 ADAM17 decreases responsiveness to IL-33.

Figure 1:

(A) tSNE analysis from lung of RoraYFP mice showing YFP expression limited to ILC2 cluster. (B) WT and ADAM17ILC2−/− mice were challenged i.n. with IL-33 and ILC2s were measured in the lung. (C) IL-5 and IL-13 were measured by flow cytometry on ILC2s from B. (D) Eosinophil numbers in BALF from mice in B were measured by flow cytometry. (E) Representative histological sections of lungs from IL-33 challenged mice. *P < 0.05, **P < 0.01, ****P < 0.0001, one-way ANOVA (B-D). Data are pooled from three (mean ± s.d.) independent experiments.