Table II:
Germline Alterations Found and Corresponding Clinical Characteristics
| Germline Alteration | LOH | Pathology | Ethnicity | Age @ Diagnosis | Stage at Initial Diagnosis | Resection (Y/N) | Metastatic Disease (Y/N) | Metastatic Chemotherapy | Survival from Diagnosis (Months) |
|---|---|---|---|---|---|---|---|---|---|
| ATM- c.8266A>T(p.Lys2756Ter) | Yes | Pancreaticobiliary | White | 67 | IIB | Y | Y | mFOLFIRINOX* | 16 |
| ATM– c.9023G>A (p.Arg3008His) | Yes | Pancreaticobiliary | White | 69 | IIB | Y | N | NA | 2 |
| BRCA2– c.3420dupT (p.Thr1141Tyrfs*3) | Yes | Intestinal | Ashkenazi Jewish | 45 | IIB | Y | N | Gemcitabine & Cisplatin | 2 |
| BRCA2- c.9285C>A (p.Asp3095Glu) | Yes | Pancreaticobiliary | Top Eastern | 35 | IV | N | Y | Gemcitabine & Cisplatin* | 18 |
| BRCA2- c.5946delT (p.Ser1982Argfs) | No | Pancreaticobiliary | Ashkenazi Jewish | 73 | IIB | Y | Y | Gemcitabine & Cisplatin | 84 |
*
No longer on this therapy at the time of data cutoff