. Author manuscript; available in PMC: 2019 Dec 13.

Published in final edited form as: J Med Chem. 2018 Nov 30;61(23):10910–10921. doi: 10.1021/acs.jmedchem.8b01671

Table 3. Titration of Y-T. cruzi CYP51A and L. infantum CYP51 with Compounds 7 and 9.

VNI and VFV were used as positive controls. CYP51 concentration was 0.5 μM, concentration range of the inhibitors was 0.1–1 μM. Titration curves axes: X, concentration range of the inhibitors (0.1 −1 μM); Y, absorbance changes in the difference spectra Δ(A₄₃₀-A₄₁₁).

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