Table 1:
Effect of tsMHC-II in murine models
Tumor Site(s) of Origin | MHC-II induced by transduction of | tsMHC-II associated with | Ref(s) |
---|---|---|---|
Breast, sarcoma, lung, colon | IFNG, MHC-II (Ak), Ciita | Tumor rejection and/or inhibited growth | 18,100,101,106–108 |
Breast, lung, colon | Ciita | Resistance to challenge with parental cells | 18,107 |
Lung | Ciita | Increased tumor growth (only in high MHC-II expressing clones) | 103 |
Sarcoma, Lung | MHC-II and Ii or Ciita | No change in tumor growth | 28,103,104 |
Breast, Lung | IFNG, Ciita | Vaccination with killed tumor cells leads to resistance to re-challenge with parental | 100,103,107,134,135 |
Breast | Ciita | IFN-γ production by splenocytes | 18 |