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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: Clin Cancer Res. 2018 Nov 21;25(8):2392–2402. doi: 10.1158/1078-0432.CCR-18-3200

Table 1:

Effect of tsMHC-II in murine models

Tumor Site(s) of Origin MHC-II induced by transduction of tsMHC-II associated with Ref(s)
Breast, sarcoma, lung, colon IFNG, MHC-II (Ak), Ciita Tumor rejection and/or inhibited growth 18,100,101,106108
Breast, lung, colon Ciita Resistance to challenge with parental cells 18,107
Lung Ciita Increased tumor growth (only in high MHC-II expressing clones) 103
Sarcoma, Lung MHC-II and Ii or Ciita No change in tumor growth 28,103,104
Breast, Lung IFNG, Ciita Vaccination with killed tumor cells leads to resistance to re-challenge with parental 100,103,107,134,135
Breast Ciita IFN-γ production by splenocytes 18
HHS Vulnerability Disclosure