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. Author manuscript; available in PMC: 2019 Apr 17.
Published in final edited form as: ACS Chem Neurosci. 2018 Oct 16;10(4):2033–2044. doi: 10.1021/acschemneuro.8b00360

Figure 6.

Figure 6.

VMAT2 blocker depletes readily releasable pools of dopamine faster in aGH compared to aSI rats. (A) Raw values of electrically stimulated dopamine release in the presence of Ro-04-128/000. Readily releasable pools deplete after eight or nine stimulations in NAc slices from aGH rats and ca. 11 to 12 stimulations in NAc slices from aSI rats. Posthoc analysis revealed significant differences between dopamine release in the two groups at baseline and first through the ninth stimulations. (B) Percent baseline representation of the data shown in (A). A lower number of stimulations was required to deplete readily releasable dopamine pools in aGH compared to aSI rats. Posthoc analysis revealed a significant difference in percent dopamine release at the sixth, seventh, and eighth stimulations. (C) Mean number of stimulations required to deplete the readily releasable dopamine pools were significantly greater in aSI compared to aGH rats. Group housed, aGH, blue, n = 5; Socially isolated, aSI, red, n = 5; *p < 0.05, **p < 0.01; ***p < 0.001; ****p < 0.0001.