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. Author manuscript; available in PMC: 2020 Jan 24.
Published in final edited form as: J Med Chem. 2019 Jan 2;62(2):467–479. doi: 10.1021/acs.jmedchem.8b01561

Scheme 3. Synthesis of Biphenyl Glycosides Evaluating Effect of N-Substitution of GalNAc Ringa.

Scheme 3.

aReagents and conditions: (a) ACN, 80 °C, 2 h; (b) DCM, (CF3CO)2O/TEA, rt, 1 h; (c) DCM, MsCl/TEA, rt, 3 h; (d) Pd(PPh3)4, Cs2CO3, 1,4- dioxane/water (5:1), 80 °C, 1 h; (e) 33% methylamine in absolute ethanol, rt, 1 h.

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