Table 1.

Biological Data for Biphenyl Galactosides and Galactosaminosides 1, 29−51

compd	R1	R2	R3	IC50(μM)a,b
1	COOH	H	H	0.64
29	COOH	NO2	H	2.2
30	COOH	NO2	H	0.28
31	COOH	H	OMe	3.9
32	OH	H	H	0.70
33	OSO2Me	H	H	0.89
34	OH	H	OMe	0.51
35	OSO2Me	H	OMe	3.7
36	F	H	H	1.5
37	OMe	H	H	2.0
38	NO2	H	H	2.7
39	CN	H	H	0.97
40	CF3	H	H	1.5
41	SO2Me	H	H	0.70
42	CH2OH	H	H	0.63
43	NHCOMe	H	H	0.31
44	NHCOCF3	H	H	0.37
45	NHCO2Me	H	H	0.63
46	CON(Me)2	H	H	3.1
47	CONHMe	H	H	3.4
48	CONH2	H	H	1.6
49	NHSO2CF3	H	H	1.1
50	NHSO2Me	H	H	0.23
51	NHSO2Me	H	H	1.6

^aAll the IC₅₀ values are an average of four or more replicates

^bStandard deviations are provided in the Supporting Information