Table 2.

Substrate Scope of Trifluoromethyl Imines with Various Acrylates^a

entry	R1; 1	4	t (h)	yield of 5 (%)b	ee of 5 (%)c
1d	Me; 1A	4a	8	80 (85); 5Aa	92(92)
2e	Me; 1A	4b	3	89 (92); 5Ab	91 (93)
3d	Me; 1A	4c	20	70 (75); 5Ac	85 (90)
4d	Me; 1A	4d	20	50 (63); 5Ad	81 (86)
5e	Me; 1A	4e	8	91 (93); 5Ae	94 (94)
6d	Et; 1B	4a	5	71 (73); 5Ba	87 (90)
7	n-Bu; 1C	4a	8	63 (68); 5Ca	91 (91)
8	CH2=CH(CH2)3; 1D	4a	8	64 (68); 5Da	90 (92)
9	Ph(CH2)2; 1E	4a	8	53 (55); 5Ea	90 (88)
10f	H; 1F	4a	4	62 (70); 5Fa	90 (91)
11	Cy; 1G	4a	8	-- (--); 5Ga	-- (--)
12	Cy; 1G	4b	8	65 (63); 5Gb	91 (93)
13	CyCH2; 1H	4b	8	71 (72); 5Hb	90 (93)
14	Bn; 1I	4b	8	63 (72); 5Ib	90 (92)
15	4-BrBn; 1J	4b	8	68 (66); 5Jb	88 (91)

^aUnless noted, reactions were performed with 1 (0.2 mmol), acrylates 4 (0.4 mmol), A-1 (2.0 mol %), ethanol (20 μL) and aqueous KOH solution (2.2 μL, 50 wt %, 10 mol %) in PhMe (2.0 mL) with catalyst QD-3 (5.0 mol %) at the indicated temperature; results in parentheses were obtained from reactions catalyzed by epiQ-3 (5.0 mol %) in same conditions.

^bIsolated yield of 5.

^cDetermined by HPLC analysis.

^dReaction was performed at −40 °C.

^e1.0 mol % catalyst was used.

^fReaction was performed at −50 °C