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. Author manuscript; available in PMC: 2020 Feb 14.
Published in final edited form as: J Med Chem. 2019 Jan 3;62(3):1502–1522. doi: 10.1021/acs.jmedchem.8b01662

Figure 2.

Figure 2.

Effects of nucleoside derivatives on Tb in WT (C57BL/6J male) or AR-KO mice. Compound 9 (A-E) or 29 (F-J), both at 3 mg/kg, ip., and vehicle were dosed in wild-type mice (WT, A, F), or mice lacking A1AR (B, G), A3AR (C, H), or both A1AR and A3AR (D, I). E, J. Tb during the first 60 min after dosing, mean ±SEM, N =4 to 12/group. t-Test (2-tailed, paired or unpaired as appropriate) P values for vehicle vs compound, within genotype.