TABLE 2.
Discordance between ICD-O-3 Histological Diagnosis and WHO Grade in Diffuse Gliomas
| ICD-O-3 Histology |
Have WHO grade (n) |
WHO grade |
n | % | Age (years) | Overall Survival (months) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median | IQR |
p- value* |
5 yr- OS |
95% CI |
p- value** |
|||||
| Diffuse OG | 3,176 | I | 51 | 1.6 | 36 | (22-52) | <0.001 | 87.2 | (71.9-94.5) | <0.001 |
| II | 2,742 | 86.3 | 41 | (32-51) | 88.1 | (86.1-89.8) | ||||
| III | 241 | 7.6 | 47 | (36-57) | 61.2 | (51.2-69.8) | ||||
| IV | 142 | 4.5 | 56 | (46-66) | 31.2 | (22.5-40.2) | ||||
| Anaplastic OG | 1,512 | I | 2 | 0.1 | 46 | (42-50) | 0.01 | no observations | <0.001 | |
| II | 25 | 1.7 | 39 | (28-54) | 65.3 | (34.6-84.3) | ||||
| III | 1,361 | 90.0 | 48 | (38-58) | 69.6 | (65.9-72.9) | ||||
| IV | 124 | 8.2 | 51 | (41-60) | 37.9 | (25.0-50.7) | ||||
| Diffuse AC | 4,182 | I | 170 | 4.1 | 31 | (18-49) | <0.001 | 77.5 | (68.8-84.1) | <0.001 |
| II | 2,748 | 65.7 | 40 | (29-55) | 63.8 | (61.4-66.0) | ||||
| III | 760 | 18.2 | 52 | (38-64) | 29.3 | (25.7-32.9) | ||||
| IV | 504 | 12.1 | 62 | (52-70) | 9.8 | (7.1-13.0) | ||||
| Anaplastic AC | 5,628 | I | 5 | 0.1 | 41 | (34-72) | <0.001 | 53.3 | (6.8-86.3) | <0.001 |
| II | 51 | 0.9 | 39 | (27-58) | 57.1 | (36.1-73.5) | ||||
| III | 5,090 | 90.4 | 50 | (35-64) | 33.3 | (31.5-35.2) | ||||
| IV | 482 | 8.6 | 54 | (40-67) | 18.8 | (14.4-23.7) | ||||
| Glioblastoma | 40,333 | I | 83 | 0.2 | 62 | (51-71) | 0.008 | 10.6 | (2.7-24.9) | 0.08 |
| II | 66 | 0.2 | 60 | (46-69) | 10.8 | (2.5-26.0) | ||||
| III | 356 | 0.9 | 62 | (53-72) | 9.6 | (5.7-14.5) | ||||
| IV | 39,828 | 98.7 | 62 | (54-71) | 7.6 | (7.1-8.0) | ||||
**
p-value from a log-rank test using Kaplan-Meier survival analysis
*
p-value from an ANOVA test;
OG: oligodendroglioma, AC: astrocytoma, IQR: interquartile range, OS: overall survival, CI: confidence interval;