aSyn is a N-terminally acetylated protein with 140 residues that is divided into three distinct domains: an amphipathic N-terminal domain, a central hydrophobic domain (denoted as Non-Amyloid-β Component: NAC), and an acidic C-terminal domain. All familial aSyn mutations (A53T, A30P, E46K, H50Q, G5 ID and A53E) are located into N-terminal domain.