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. Author manuscript; available in PMC: 2020 Jan 16.
Published in final edited form as: ACS Chem Neurosci. 2018 Nov 5;10(1):690–703. doi: 10.1021/acschemneuro.8b00498

Figure 1. Location of PD-linked mutations into aSyn sequence.

Figure 1.

aSyn is a N-terminally acetylated protein with 140 residues that is divided into three distinct domains: an amphipathic N-terminal domain, a central hydrophobic domain (denoted as Non-Amyloid-β Component: NAC), and an acidic C-terminal domain. All familial aSyn mutations (A53T, A30P, E46K, H50Q, G5 ID and A53E) are located into N-terminal domain.