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Inhibition efficacies of macrocyclic AAR029b and FITC-AAR029b. CD4 and 17b IC50 values were determined by competition SPR. Antiviral EC50 values were obtained by a single round cell infection assay and expressed as relative infection versus untreated (100%).
| cPT | CD4 (IC50, nM) |
17b (IC50, nM) |
Bal.01 (EC50, nM) |
|---|---|---|---|
| AAR029b | 140±15 | 145 ±21 | 210 ±10 |
| FITC-AAR029b | 128±10 | 135 ±19 | 320 ±20 |
