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. 2019 Apr 16;9:6118. doi: 10.1038/s41598-019-42630-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ectopic Dpp signaling in CySCs promotes vn expression. (a) EGFR signaling activation (by pERK, red) in c587^tscontrol testis. pERK signal is mainly observed in the early cyst cells (white arrowheads). (b) EGFR signaling is highly activated in the somatic cyst cells of c587^ts > tkv^CA testis. (c) Quantification of fluorescence intensity of pERK in control and c587^ts > tkv^CA testes. n = 10. (d) EGFR signaling activation (by kek-lacZ, red) in c587^ts control testis. kek-lacZ is expressed in the somatic cyst cells (white arrowheads). (e) kek-lacZ is highly expressed in c587^ts > tkv^CA testis. (f) Quantification of the fluorescence intensity of kek-lacZ in control and c587^ts > tkv^CA testes. n = 10. (g) vn expression (by vn-lacZ, red) in c587^ts control testis. vn-lacZ is expressed at low levels in the early cyst cells (white arrowheads). (h) vn-lacZ is highly expressed in c587^ts > tkv^CA testis. (i) Quantification of the fluorescence intensity of vn-lacZ in control and c587^ts > tkv^CA testes. n = 10. mean ± SEM is shown. **p < 0.01. GFP in green, blue indicates DAPI staining for DNA. Scale bars: 10 μm.