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. 2019 Apr 16;9:6114. doi: 10.1038/s41598-019-42273-z

Table 1.

Antileishmanial activity and mammalian cytotoxicity of the semi-synthetic compounds 1–4.

Compound IC50 (µM) ± SD CC50 (µM) ± SD NCTC SI
Promastigote Amastigote
1 93.3 ± 8.4 35.9 ± 6.6 75.0 ± 13.8 2.1
2 105.4 ± 9.4 6.1 ± 1.2 >200 >32.8
3 29.6 ± 2.3 21.7 ± 1.9 57.7 ± 1.1 2.7
4 29.0 ± 0.2 34.5 ± 11.4 >200 >5.8
Miltefosine 5.1 ± 0.6 6.5 ± 3.0 119.7 ± 4.2 18.4

IC50: 50% Inhibitory Concentration; CC50: 50% Cytotoxic Concentration; SI: Selectivity Index, given by the ratio between CC50 in NCTC cells and IC50 in intracellular amastigotes; SD: Standard Deviation.