Table 1.
Clinical and biochemical characteristics in PCOS patients and controls.
| PCOS (n = 600) | ||||||
|---|---|---|---|---|---|---|
| Characteristicsa | nonHA (n = 229) | HA (n = 371) | Pc | Total | Control (n = 200) | Pd |
| Age (years) | 27.73 ± 4.90 | 27.63 ± 5.40 | 0.822 | 27.67 ± 5.21 | 28.26 ± 5.29 | 0.170 |
| BMI (kg/m2)b | 23.44 ± 4.70 | 28.26 ± 5.47 | <0.001 | 26.44 ± 5.69 | 26.72 ± 5.37 | 0.537 |
| Normal BMI | 150 | 104 | <0.001 | 252 (42.00) | 77 (38.50) | 0.516 |
| Overweight | 56 | 138 | 196 (32.67) | 74 (37.00) | ||
| Obese | 23 | 129 | 152 (25.33) | 49 (24.50) | ||
| WC (cm) | 79.99 ± 12.51 | 91.89 ± 14.16 | <0.001 | 87.35 ± 14.73 | 86.52 (13.90) | 0.188 |
| WHR | 0.85 ± 0.09 | 0.89 ± 0.07 | <0.001 | 0.88 ± 0.08 | 0.87 ± 0.08 | 0.249 |
| TSH (mIU/L) | 2.16 ± 1.01 | 2.37 ± 1.37 | 0.045 | 2.29 ± 1.24 | 1.86 ± 0.90 | <0.001 |
| Phenotype | <0.001 | |||||
| HA-O-PCO | 0 | 190 | 190 (31.67) | NA | ||
| O-HA | 0 | 86 | 86 (14.33) | NA | ||
| PCO-HA | 0 | 95 | 96 (16) | NA | ||
| PCO-O | 229 | 0 | 228 (38) | NA | ||
| HA phenotype | 0 | 371 | <0.001 | 371 (61.83) | NA | |
| AIT | 53 (23.14) | 66 (11.18) | 0.11 | 119 (19.83) | 34 (17.00) | 0.378 |
| TGAB positive | 47 (20.32) | 60 (16.11) | 0.176 | 107 (17.83) | 29 (14.50) | 0.277 |
| TPOAB positive | 27 (11.13) | 30 (8.09) | 0.133 | 57 (9.50) | 19 (9.50) | 1.000 |
| TG (mmol/L) | 0.90 (0.67–1.37) | 1.37 (1.01–2.02) | <0.001 | 1.19 (0.82–1.81) | 1.01 (0.69–1.57) | 0.002 |
| Tch (mmol/L) | 4.61 ± 0.96 | 4.88 ± 0.99 | 0.001 | 4.78 ± 0.99 | 4.63 ± 0.91 | 0.070 |
| HDL (mmol/L) | 1.51 ± 0.40 | 1.23 ± 0.32 | <0.001 | 1.34 ± 0.38 | 1.43 ± 0.40 | 0.006 |
| LDL (mmol/L) | 2.57 ± 0.72 | 2.95 ± 0.81 | <0.001 | 2.8 ± 0.80 | 2.63 ± 0.76 | 0.007 |
| apoA (mg/L) | 125.00 (41–252) | 108.00 (48.95–259.00) | 0.68 | 112.9 (46.23–253.45) | 107.45 (41.00–259.50) | 0.302 |
| apoB (g/L) | 0.85 ± 0.23 | 1.00 ± 0.28 | <0.001 | 0.95 ± 0.27 | 0.88 ± 0.27 | 0.007 |
| LH (IU/L) | 8.72 ± 7.03 | 8.86 ± 6.01 | 0.787 | 8.81 ± 6.41 | 8.07 ± 7.31 | 0.201 |
| FSH (IU/L) | 6.40 ± 2.56 | 6.12 ± 3.50 | 0.205 | 6.23 ± 2.50 | 7.31 ± 5.48 | 0.012 |
| LH/FSH | 1.47 ± 1.15 | 1.50 ± 0.98 | 0.759 | 1.49 ± 1.05 | 1.21 ± 0.90 | 0.001 |
| PRL (ug/L) | 12.59 (8.96–19.36) | 11.55 (8.76–16.02) | 0.095 | 11.95 (8.96–16.92) | 12.68 (9.40–16.62) | 0.726 |
| E2 (pmol/L) | 183.00 (110.75–300.50) | 168.00 (125.00–243.00) | 0.338 | 174.00 (116.50–259.00) | 172 (121.50–276.50) | 0.956 |
| T (nmol/L) | 1.79 ± 0.75 | 2.53 ± 0.92 | <0.001 | 2.25 ± 0.93 | 1.73 ± 0.75 | <0.001 |
| FT | 25.35 ± 9.68 | 61.21 ± 21.89 | <0.001 | 47.52 ± 25.21 | 27.05 ± 13.73 | <0.001 |
| FAI | 3.73 (2.76–5.23) | 12.46 (9.43–17.73) | <0.001 | 8.68 (4.66–14.17) | 4.32 (2.74–5.68) | <0.001 |
| mean ovary volume (ml3) | 50.53 ± 24.12 | 19.62 ± 9.16 | <0.001 | 10.41 ± 4.54 | 5.69 ± 1.26 | <0.001 |
| SHBG (nmol/L) | 202.50 (149.25–258.75) | 257.00 (183.75–321.25) | <0.001 | 24.2 (15.93–42.28) | 39 (28.60–58.10) | <0.001 |
| DHEAs (ng/mL) | 3.78 ± 2.16 | 4.58 ± 2.26 | <0.001 | 243.33 ± 104.59 | 198.31 ± 93.20 | <0.001 |
| A2 (ug/dL) | 10.88 ± 4.92 | 10.10 ± 4.26 | 0.061 | 4.28 ± 2.26 | 2.94 ± 1.66 | <0.001 |
WC, waist circumference; WHR, waist to hip ratio; HA, hyperandrogenism; AIT, autoimmune-thyroiditis; FT, free testosterone; FAI, free androgen index; SHBG, sex hormone binding globulin; DHEAs, dehydroepiandrosterones.
a
Continuous data are shown as mean ± sd or medians (IQR) and categorical variables as n (%).
b
Body mass index was calculated as weight (kg)/height (m)2.
c
P-value for nonHA vs. HA PCOS.
d
P-value for PCOS vs. control.