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. 2019 Apr 10;10:735. doi: 10.3389/fimmu.2019.00735

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Copyright © 2019 Phaahla, Lassaunière, Da Costa Dias, Waja, Martinson and Tiemessen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FcγRIIIa expression on NK cell subsets in HIV-1 uninfected and HIV-1 infected individuals matched for FCGR genetic variants. (A) Gating strategy for defining four NK cell subsets: 1. CD56^brightFcγRIIIa^dim/neg, 2. CD56^dimFcγRIIIa^bright, 3. CD56^dimFcγRIIIa^dim/neg, and 4. CD56^negFcγRIIIa^bright; (B) Comparison of NK cell subsets between HIV-1 uninfected and infected individuals; (C) FcγRIIIa surface density on FcγRIIIa^bright NK cell subsets; (D) ADCC activity of NK cells at a target-to-effector cell ratio of 10:1 with isolated IgG pooled from HIV-1 study participants; (E) Median ADCC responses for individuals homozygous for the FcγRIIIa-158F allele and individuals bearing at least one FcγRIIIa-158V allele; (F) Correlation analysis between demographic, clinical, phenotypic and functional variables in HIV-1 uninfected and HIV-1 infected individuals (^***P < 0.001; ^**P < 0.01; ^*P < 0.05).