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. 2019 Apr 10;10:735. doi: 10.3389/fimmu.2019.00735

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Copyright © 2019 Phaahla, Lassaunière, Da Costa Dias, Waja, Martinson and Tiemessen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FcγRIIIa expression on CD8 T cells in HIV-1 uninfected and HIV-1 infected individuals matched for FCGR genetic variants. (A) Gating strategy; (B) The proportion of FcγRIIIa⁺CD8^bright and FcγRIIIa⁺CD8^dim T cells and corresponding median fluorescence intensity (MFI) of FcγRIIIa on these FcγRIIIa⁺CD8⁺ T cell subsets in a cohort of HIV-1 uninfected and infected individuals; (C) Correlation analysis between demographic, clinical, phenotypic, and functional variables in HIV-1 uninfected and HIV-1 infected individuals; (D) CD8⁺ T cell-mediated ADCC responses of HIV-1 positive donors relative to autologous NK cell-mediated ADCC responses at the same effector-to-target cell ratio (^***P < 0.001; ^**P < 0.01; ^*P < 0.05).