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Rickettsia conorii switches macrophage immune responses into a hyporesponsive state. Quantification of TNFα concentration in the culture media of uninfected (white), R. conorii- (black) and R. montanensis-infected (blue) THP-1 macrophages upon stimulation with E. coli O26:B6 LPS. Results are shown as mean ± SD and differences were considered non-significant (ns) at P > 0.05 or significant at **P ≤ 0.01, ***P ≤ 0.001.
