Skip to main content
. 2019 Apr 10;10:382. doi: 10.3389/fphys.2019.00382

Figure 2.

Figure 2

Parkin-mediated mitophagy flux is significantly elevated in aging hearts but impaired in HF. (A) Representative images of mCherry-Parkin and GFP-LC3 puncta distribution in young, aged control and HF myocytes. (B) Average puncta size in young, aged and HF myocytes. (C) Average puncta count per cell in young, aged and HF myocytes. (D) Cell size differences in young, aged and HF myocytes. (E) Puncta count normalized per cell size in young, aged and aged HF myocytes. Data expressed as mean ± SEM. n = number of cells from four young, five aged and six HF animals. *p < 0.05 reflects the difference in aged and HF myocytes vs. young; #p < 0.05 aged vs. HF myocytes.