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. 2018 Nov 12;10(5):370–375. doi: 10.1007/s13238-018-0591-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Change of heterogeneity and transcriptome profile of HCA2 fibroblasts with replicative senescence. (A) Schematic of replicatively senescent HCA2 fibroblast single-cell transcriptomics. (B) t-distributed stochastic neighbour embedding (t-SNE) plot of Drop-seq mRNA sequencing data from PD38 quiescent cells, PD48 quiescent cells and replicatively senescent cells. Cells were clustered into 5 distinct sub-populations. (C) Same as in (B), with cells color-coded by sample of origin. (D) Enriched pathways of up-regulated genes of cluster 1–3, the length and color of the bar show the significance of each cluster’s enriched pathways. Left barplot. Cluster 3-specific enriched pathways of cluster 3’s up-regulated genes. Bottom barplot. Cluster 3 and cluster 2 common enriched pathways of cluster 2’s and cluster 3’s up-regulated genes. Right barplot. Cluster 2-specific enriched pathways of cluster 2’s up-regulated genes