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Human β-arrestin-2 translocation to V2R and D2R.
| hβ-Arrestin-2 |
||||||
|---|---|---|---|---|---|---|
| V2R |
D2R |
D2R + GRK2 |
||||
| logEC50 (±SEM) | Emax (±SEM) (ΔBRET.sec) | logEC50 (±SEM) | Emax (±SEM) (ΔBRET.sec) | logEC50 (±SEM) | Emax (±SEM) (ΔBRET.sec) | |
| AVP | –8.27 ± 0.05 | 305.9 ± 30.8 | X | X | X | X |
| Dopamine | X | X | –6.40 ± 0.03 | 72.9 ± 1.5 | –7.27 ± 0.04Δ | 132.0 ± 10.9Δ |
X, not determined. ΔValue is significantly different in the presence of GRK2 compared to the absence of GRK2 for the same ligand.
