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Bovine β-arrestin-1 translocation to V2R and D2R.
| bβ-Arrestin-1 |
||||
|---|---|---|---|---|
| V2R |
D2R |
D2R + GRK2 |
||
| logEC50 ± SEM (M) | Emax ± SEM (ΔBRET.sec) | Response ± SEM (ΔBRET.sec) | Response ± SEM (ΔBRET.sec) | |
| AVP | –8.237 ± 0.04 | 176.9 ± 10.9 | X | X |
| 10 μM dopamine | X | X | 23.4 ± 4.1 | 95.0 ± 13.3Δ |
X, not determined. ΔValue is significantly different in the presence of GRK2 compared to the absence of GRK2 for the same ligand.
