Table 6.

Bovine β-arrestin-1 translocation to CB₁ and CB₂.

	bβ-Arrestin-1
	CB1	CB1 + GRK2	CB2	CB2 + GRK2
	Response ± SEM (ΔBRET.sec)	Response ± SEM (ΔBRET.sec)	Response ± SEM (ΔBRET.sec)	Response ± SEM (ΔBRET.sec)
1 μM CP55,940	20.8 ± 4.9§	44.4 ± 2.3§,Δ	21.5 ± 4.2§	29.0 ± 1.9§
31.6 μM 2-AG	33.7 ± 6.2§	49.1 ± 4.2§,Δ	14.2 ± 4.3	17.5 ± 1.7§
10 μM WIN55,212-2	48.5 ± 5.5§	X	22.2 ± 4.7§	X
10 μM AEA	6.9 ± 3.6	X	X	X
10 μM THC	6.5 ± 5.1	X	10.8 ± 2.6	X
10 μM BAY	0.7 ± 4.2	X	X	X
10 μM JWH-015	X	X	14.2 ± 3.7	X
10 μM JWH-133	X	X	7.4 ± 5.3	X

X, not determined. ^§Value is significantly different from vehicle control. ^ΔValue is significantly different in the presence of GRK2 compared to the absence of GRK2 for the same ligand.