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Human β-arrestin-1 translocation to V2R and D2R.
| hβ-Arrestin-1 |
||||
|---|---|---|---|---|
| V2R |
D2R |
D2R + GRK2 |
||
| logEC50 ± SEM (M) | Emax ± SEM (ΔBRET.sec) | Response ± SEM (ΔBRET.sec) | Response ± SEM (ΔBRET.sec) | |
| AVP | –8.33 ± 0.03 | 246.3 ± 21.8 | X | X |
| 10 μM dopamine | X | X | 17.9 ± 3.3 | 86.1 ± 14.5Δ |
X, not determined. ΔValue is significantly different in the presence of GRK2 compared to the absence of GRK2 for the same ligand.
