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. 2019 Apr 17;39(16):3013–3027. doi: 10.1523/JNEUROSCI.2922-18.2019

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Copyright © 2019 Goncalves et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — RARα-mediated myelination in RARβ-agonist-treated avulsed rats. A, Expression of both PLP and MAG are upregulated in the RARβ-treated rats and both types of myelin show an unbroken pattern (inset). B, C, Quantification of PLP and MAG shows a significant increase in response to RARβ treatment. Data show mean ± SEM, n = 8 per treatment group, **p ≤ 0.01, Student's t test. D, RARα, but not RARβ, is upregulated in NG2⁺ cells in the dorsal horn of RARβ-agonist-treated rats (see arrows). E, Expression of RARα and NG2 in vehicle- and RARβ-agonist-treated rats shows an upregulation of RARα in the nucleus (seen in dark pink and indicated with white arrows) in C286-treated rats. F, G, Quantification of RARα in NG2 cells is significantly higher in this group (F) as is the total RARα expression (G) compared with vehicle-treated rats. Data are shown as mean ± SEM, n = 8 per treatment, ***p ≤ 0.001, Student's t test. H–J, There is a high coexpression of Olig1 and RARα in RARβ-agonist-treated rats (H), with the percentage of Olig1⁺ cells expressing RARα (I) being significantly higher in this group compared with vehicle-treated rats, as is the total number of Olig1⁺ cells per field (J). Data are shown as mean ± SEM, n = 8 ***p ≤ 0.001, Student's t test. Scale bars, 100 μm.