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. 2019 Apr 17;39(16):3081–3093. doi: 10.1523/JNEUROSCI.1786-18.2019

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Copyright © 2019 Moriarty et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Incision, neonatal minocycline, and sex influence expression of microglial-related genes in the medial ipsilateral dorsal horn. A, Expression of Emr1 increased 3 d following single adult incision (IN) in males and females. B, Expression of Irf8 increased following IN. A, B, Data normalized to age- and sex-matched naive rats. C, Expression of Emr1 was lower in males than females following neonatal minocycline and reincision (nmIN-IN). Male nmIN-IN versus female nmIN-IN: p = 0.023. D, Expression of Irf8 was lower in males than females following neonatal minocycline and reincision (male nmIN-IN vs female nmIN-IN: p = 0.019). C, D, nmIN-IN data normalized to saline repeat incision (nsIN-IN). A–D, Data points are individual units with each including 2 animals (n = 6–9 units per group). Error bars indicate ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; two-way ANOVA with sex and group as variables and Bonferroni post hoc comparisons.