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. 2019 Jan 18;47(7):3485–3502. doi: 10.1093/nar/gkz025

Figure 6.

Figure 6.

R-loop-dependent ATM activation in WS cells after mild replication stress. Analysis of DSB accumulation evaluated by neutral Comet assay in WS cells subjected to chemical inhibition of ATM and transcription as reported in the experimental scheme. After treatment, cells were harvested and subjected to neutral Comet assay. Dot plot shows data presented as mean tail moment ± SE from three independent experiments. Horizontal black lines represent the mean. (ns, not significant; ****P < 0.0001; two-tailed Student's t test).