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. 2019 Mar 19;196(2):226–236. doi: 10.1111/cei.13263

Figure 5.

Figure 5

High frequencies of Ki67+ natural killer (NK) cells are present in patients with decreased levels of complement as well as active nephritis. (a) Linear regression analysis of serum C3 and C4 proteins in systemic lupus erythematosus (SLE) patients. Statistical analyses performed using Pearson’s correlation. (b) Top: contingency table of patients ranked based on Ki67hi NK cells (> 40% Ki67+ NK cells) or Ki67mid/lo (< 40% Ki67+ NK cells) comparing serum complement as either low (< 90 mg/dL C3 and < 10 mg/dL C4) or normal at the time of visit and blood draw. Sensitivity and specificity of test = 34·3 and 96·8%. Positive predictive value = 78·5%. Bottom: contingency table of patients ranked based on Ki67hi NK cells (> 40% Ki67+) or Ki67mid/lo (< 40% Ki67+ NK cells) comparing active or no nephritis at the time of visit and blood draw. Sensitivity and specificity of test = 34·3 and 94·4%. Positive predictive value = 57·9%. Statistical analysis was performed using Fisher’s exact test.