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. 2019 Feb 17;196(2):139–154. doi: 10.1111/cei.13262

Figure 7.

Figure 7

Summary of the long‐term effects of MSC on experimental colitis. TNBS (2,4,6‐trinitrobenzene sulfonic acid) enema triggered intestinal inflammation in mice by enhancing Th1 and Th17 response and reducing Th2 cells. An early and unique intraperitoneal (i.p.) administration of adipose tissue‐derived MSC (mesenchymal stromal cells) produced persistent protective effects on bowel inflammatory response by constraining inflammation and restoring Th1/Th17/Th2 balance.