Table 6. Physicochemical parameters of the three lead compounds .
| LogP | MW | TPSA | HBD | HBA | nrotb | |
| Compound A1 | 2.02126 | 278.695 | 113.553 | 2 | 3 | 1 |
| Compound A2 | 3.01496 | 279.723 | 114.578 | 2 | 3 | 1 |
| Compound A3 | 2.82096 | 267.712 | 109.165 | 2 | 3 | 1 |
| Compound A4 | 3.83116 | 305.683 | 116.548 | 2 | 2 | 0 |