Figure 5.

The effects of RO27‐3225 (RO) on neuronal degeneration and pyroptosis at 24 hr after ICH. (a, b) Representative microphotographs and quantitative analysis of Fluoro‐Jade C (FJC) positive degenerating neurons in the perihaematomal area. (c, d) Representative microphotographs and quantitative analysis of TUNEL‐positive neurons in the perihaematomal area. (e, f) Representative microphotographs and quantitative analysis of cleaved caspase‐1 (C‐caspase‐1)‐positive neurons in the perihaematomal area. Scale bar = 50 μm. Data shown are individual values with mean ± SD; n = 6. *P < 0.05, significantly different from sham, ^# P < 0.05, significantly different from ICH + vehicle; one‐way ANOVA, Tukey's test