Figure 2.

Representative direct current (DC) potential and cerebral blood flow (CBF) traces of the full experimental protocol including common carotid artery occlusion (2VO) in Series 2 under vehicle (upper box) or nimodipine (lower box) treatment. The traces were downsampled to 1‐Hz frequency (original sampling frequency: 500 or 2000 Hz), and the CBF traces were smoothed by median filtering for 6 data points. Note that nimodipine gradually elevated baseline perfusion, increased the amplitude of functional hyperaemia to whisker stimulation, and enlarged hyperaemia in response to the first (SD1) and recurrent spreading depolarizations (rSD). Also, nimodipine reduced SD amplitude. Note also the strikingly different size of the CBF response to whisker stimulation and SD within the same preparation